Abstract
AbstractOxidoreductases (ORases) are enzymes that catalyze oxidation and reduction reactions in cells or extracellular compartments of the body. Genetic mutations and other factors that affect ORase activity have been implicated in a range of diseases, especially inherited metabolic disorders. Aldose reductase, sorbitol dehydrogenase, xanthine oxidoreductase are the ORases with relevance to diabetes pathology. Herein, the strategies for screening modulators of ORase activities, and medicinal plants whose phytochemicals have the potential to influence ORase activity, are described. The overall goal is to test and identify natural products and other compounds that may have a therapeutic benefit in relation to hyperglycemia and diabetes.
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