Abstract
AbstractStructure‐activity relationship (SAR) studies of the natural pesticidal peptide, tentoxin, are described in the context of similarity between pharmaceutical and agricultural methods of developing biologically active peptidomimetics. Essential residue substitutions that confer biological activity through predictable conformational changes in the peptide backbone and side chain functionalities are discussed. A combination of molecular modelling studies and the biological activity of natural, synthetic and photochemically transformed analogs of tentoxin is utilized to further the understanding of structural and conformational requirements for biological activity.
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