Abstract
<p class="Abstract">The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of <em>Mimosa pudica</em>. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with <em>M. pudica</em> ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of <em>M. pudica</em> leaf is effective in the treatment of ulcerative colitis.</p><p class="Abstract"><strong>Video Clip of Methodology:</strong></p><p class="Abstract">Embedding or block making: 24 sec <a href="https://www.youtube.com/v/Y1I4tKYMLsE">Full Screen</a> <a href="https://www.youtube.com/watch?v=Y1I4tKYMLsE">Alternate</a></p><p class="Abstract">Tissue processing: 19 sec <a href="https://www.youtube.com/v/7nYpxL2qPhg">Full Screen</a> <a href="https://www.youtube.com/watch?v=7nYpxL2qPhg">Alternate</a></p><p class="Abstract">Section cutting: 33 sec <a href="https://www.youtube.com/v/_amFL9kNLBw">Full Screen</a> <a href="https://www.youtube.com/watch?v=_amFL9kNLBw">Alternate</a></p>
Highlights
Ulcerative colitis and Crohn’s disease are the two major types of inflammatory bowel diseases
The aim of present investigation is to evaluate the potential of various extracts of M. pudica leaf in the treatment of inflammatory bowel diseases like ulcerative colitis in the rat model
Prednisolone and acetic acid treatment were started on the same day; Group IV, VI, VIII received 7 days pretreatment with 200 mg/kg of ethanol, ethyl acetate, chloroform extract of M. pudica respectively, p.o. and 1 mL of 4% acetic acid solution, intrarectally on day 8
Summary
Ulcerative colitis and Crohn’s disease are the two major types of inflammatory bowel diseases. The pathophysiology of ulcerative colitis has highlighted the importance of cytokines like tumor necrosis factor(TNF- ), interleukin-1 (IL-1 ), IL-6 and IL-8, which are responsible for the production of reactive oxygen species which activates the oxidative stress-responsive gene that plays an important role in development and maintenance of inflammatory bowel diseases (Oz et al, 2005). Corticosteroid, 5-aminosalicylate, sulfasalazine, methotrexate, prednisolone and immunosuppressive agents (mercaptopurine and azathioprine) are the recent treatment regimens for inflammatory bowel diseases. The aim of present investigation is to evaluate the potential of various extracts of M. pudica leaf in the treatment of inflammatory bowel diseases like ulcerative colitis in the rat model
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