Abstract
Cell-based therapy is a promising treatment to favor tissue healing through less invasive strategies. Mesenchymal stem cells (MSCs) highlighted as potential candidates due to their angiogenic, anti-apoptotic and immunomodulatory properties, in addition to their ability to differentiate into several specialized cell lines. Cells can be carried through a biological delivery system, such as fibrin glue, which acts as a temporary matrix that favors cell-matrix interactions and allows local and paracrine functions of MSCs. Thus, the aim of this systematic review was to evaluate the potential of fibrin glue combined with MSCs in nerve regeneration. The bibliographic search was performed in the PubMed/MEDLINE, Web of Science and Embase databases, using the descriptors (“fibrin sealant” OR “fibrin glue”) AND “stem cells” AND “nerve regeneration”, considering articles published until 2021. To compose this review, 13 in vivo studies were selected, according to the eligibility criteria. MSCs favored axonal regeneration, remyelination of nerve fibers, as well as promoted an increase in the number of myelinated fibers, myelin sheath thickness, number of axons and expression of growth factors, with significant improvement in motor function recovery. This systematic review showed clear evidence that fibrin glue combined with MSCs has the potential to regenerate nervous system lesions.
Highlights
The nervous system is a highly specialized tissue, responsible for the functional sensory and motor activity of the organism
The outcomes of these studies showed that the association of fibrin glue with Mesenchymal stem cells (MSCs) significantly favored axonal regeneration and myelination of nerve fibers compared to the use of fibrin glue without cells [44,45,48,50–52]
Similar results were obtained by Goel et al (2019), who reported that sciatic nerve regeneration was more significant in the group treated with fibrin glue and MSCs at 30 and 60 days after surgery, while degenerative changes, such as ballooning of axons and degeneration of the sheath of myelin, were more prominent in the group treated only with fibrin glue [44]
Summary
The nervous system is a highly specialized tissue, responsible for the functional sensory and motor activity of the organism. The nervous system is susceptible to trauma by mechanical, electrical and thermal action, as well as by ischemic compression or drug injection [1,2]. The severity of the sequelae and the tissue recovery ability depends on the nature and extent of the injury. Adequate functional recovery of this tissue is still a major challenge, especially in large-scale injuries [2,3]. In most cases, therapeutic and surgical interventions are essential to encourage the regeneration of the nervous system [2,4]. The late or inadequate interventions can cause several disorders, such as chronic pain, neuropathies, muscle atrophy, paralysis and severe functional incapacity with compromised quality of life [2,5]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
