Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman–Birk soybean proteinase inhibitor

I.P Gladysheva,O.V Polekhina,T.A Karmakova,E.R Nemtsova,R.I Yakubovskaya,W.-C Shen,A.R Kennedy,N.I Larionova

doi:10.1016/s0168-3659(01)00337-6

Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman–Birk soybean proteinase inhibitor

I.P Gladysheva, O.V Polekhina + Show 6 more

https://doi.org/10.1016/s0168-3659(01)00337-6

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Journal: Journal of controlled release : official journal of the Controlled Release Society	Publication Date: Jul 1, 2001
Citations: 5

Affiliation: Moscow State University, P.A. Hertzen Moscow Oncology Research Institute, University of Southern California, University of Pennsylvania

#Birk Protease Inhibitor #Clinical Dextran + Show 8 more

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Abstract

The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman–Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.

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