Abstract
Background and Objective: Syzygium aromaticum is an immunomodulator with the main active compound eugenol which can stimulate the function of lymphocyte proliferation and macrophage production. Lymphocytes play an important role for body protection against infection. This study aims to analyze the effect of S. aromaticum extract to increase proliferation of lymphocytes, lymphoblasts and macrophage production in Balb/c mice infected with Salmonella typhimurium. Methodology: Mice strain Balb/c were divided into 4 groups: treatment group infected with S. typhimurium and control group (without treatment) to tested the activity of peritoneal macrophages. The treatment group was administrated by S. aromaticum leaf extract (15 mg, 75 mg, 150 mg/kgbw) for 12 days. Results: S. aromaticum leaf extract increased the proliferation activity (p < 0.001) at dose of 15, 75, and 150 mg/kgbw, increased lymphocytes at dose 150 mg/kgbw (p < 0.05), increased the activity of macrophage ROI secretion at dose of 150 mg/kgbw (p < 0.05), and increased in lymphoblast (p < 0.05). Conclusion: Administration of S. aromaticum leaf extract increased the proliferation activity of lymphocytes, lymphoblasts and ROI secretion of macrophagesin Balb/c mice infected with S. typhimurium.
Highlights
Clove (Syzygium aromaticum) is Indonesian native species (Maluku) which belongs to Myrtaceae family, ordo Myrtales [1] and is one of herbal plant that has long been used in Middle Eastern and Asian countries [2]
Syzygium aromaticum is an immunomodulator with the main active compound eugenol which can stimulate the function of lymphocyte proliferation and macrophage production
This study aims to analyze the effect of S. aromaticum extract to increase proliferation of lymphocytes, lymphoblasts and macrophage production in Balb/c mice infected with Salmonella typhimurium
Summary
Clove (Syzygium aromaticum) is Indonesian native species (Maluku) which belongs to Myrtaceae family, ordo Myrtales [1] and is one of herbal plant that has long been used in Middle Eastern and Asian countries [2]. The content of clove compounds has chemical properties and pharmacological effects that function as anesthetics, antimicrobials, antiseptics, antioxidants, immunomodulators, and immunostimulants [2] [4]. Syzygium aromaticum is an immunomodulator with the main active compound eugenol which can stimulate the function of lymphocyte proliferation and macrophage production. This study aims to analyze the effect of S. aromaticum extract to increase proliferation of lymphocytes, lymphoblasts and macrophage production in Balb/c mice infected with Salmonella typhimurium. Results: S. aromaticum leaf extract increased the proliferation activity (p < 0.001) at dose of 15, 75, and 150 mg/kgbw, increased lymphocytes at dose 150 mg/kgbw (p < 0.05), increased the activity of macrophage ROI secretion at dose of 150 mg/kgbw (p < 0.05), and increased in lymphoblast (p < 0.05). Conclusion: Administration of S. aromaticum leaf extract increased the proliferation activity of lymphocytes, lymphoblasts and ROI secretion of macrophagesin Balb/c mice infected with S. typhimurium
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