Abstract
We aimed to evaluate potential new treatments for knee osteoarthritis (OA). The National Institute of Health ClinicalTrials.gov database was searched for “Osteoarthritis, Knee”. We found 565 ongoing interventional studies with a total planned enrollment of 111,276 subjects. Ongoing studies for knee OA represent a very small fraction of the registered clinical trials, but they are over a quarter of all knee trials and over two thirds of all OA studies. The most researched topic was arthroplasty, with aspects such as implant design changes, cementless fixation, robotic guidance, pain management, and fast track recovery. Intraarticular injections focused on cell therapies with mesenchymal stem cells sourced from adipose tissue, bone marrow, or umbilical cord. We could see the introduction of the first disease modifying drugs with an impact on knee OA, as well as new procedures such as geniculate artery embolization and geniculate nerve ablation.
Highlights
Osteoarthritis (OA) is the end stage degeneration of synovial joints and the knee is the most common location, with a high prevalence especially in the elderly [1]
Ongoing studies for knee OA represent a very small fraction of the registered clinical trials, but they are over a quarter of all knee trials and over two thirds of all OA studies
We could see the introduction of the first disease modifying drugs with an impact on knee OA, as well as new procedures such as geniculate artery embolization and geniculate nerve ablation
Summary
Osteoarthritis (OA) is the end stage degeneration of synovial joints and the knee is the most common location, with a high prevalence especially in the elderly [1]. Recurrent joint effusions aggravated by physical activity, synovial hypertrophy, degenerative meniscal tears, and bone edema [1,4,7]. These changes may only be evident initially on magnetic resonance imaging (MRI), but as they progress, they can be observed on plain radiographs [1,4,7,8]. End stages lead to limb deformity especially in the coronal plane (varus), incomplete extension, decreased range of motion, instability, constant pain, and serious disability [1,4,7,8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
