Potential Neurologic Side Effects of Oral Isotretinoin: A Case of Peripheral Neuropathy

Abstract

Oral isotretinoin is a well-known, effective medication used in the treatment of severe cystic acne. While efficacious, the potential side effects of isotretinoin are often discussed and may cause concern for patients. Although most side effects of this medication are mild, other more concerning adverse effects have been reported. Of note, isotretinoin has the potential to affect the central nervous system (CNS), causing headaches, pseudotumor cerebri, and fetal CNS malformations. In contrast, the effects on the peripheral nervous system are not well documented. The objective of this case report is to present an instance of oral isotretinoin leading to foot drop in an adolescent patient.