Abstract
Cervical cancer is the second most common gynecological malignancy globally; it seriously endangers women’s health because of its high morbidity and mortality. Conventional treatments are prone to drug resistance, recurrence and metastasis. Therefore, there is an urgent need to develop new drugs with high efficacy and low side effects to prevent and treat cervical cancer. In recent years, plant-derived natural products have been evaluated as potential anticancer drugs that preferentially kill tumor cells without severe adverse effects. A growing number of studies have shown that natural products can achieve practical anti-cervical-cancer effects through multiple mechanisms, including inhibition of tumor-cell proliferation, induction of apoptosis, suppression of angiogenesis and telomerase activity, enhancement of immunity and reversal of multidrug resistance. This paper reviews the therapeutic effects and mechanisms of plant-derived natural products on cervical cancer and provides references for developing anti-cervical-cancer drugs with high efficacy and low side effects.
Highlights
Introduction the Treatment of Cervical CancerCervical cancer is one of the second most common gynecologic malignancies in the world, with more than 570,000 women diagnosed with cervical cancer and 311,000 deaths annually worldwide [1]
We review the recent studies on the role and mechanisms of plant-derived natural products in the treatment of cervical cancer
epigallocatechin gallate (EGCG) treatment led to mitochondrial dysfunction through increasing reactive oxygen species (ROS) production, p53 and Bcl-2associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratios to promote cytochrome c (Cyt c) release and activation of caspase cascade, which induced apoptosis in HeLa cells [81]
Summary
We collected the relevant experimental works in the literature published in the last five years that elucidate the anticancer effects of natural products on cervical cancer, using. PUBMED (including Medline) and the Google Scholar database. Upon searching for the appropriate studies, we used “natural product, cervical cancer” as keywords. After completing the initial search, we removed duplicate works from the literature. Chemical structures of compounds derived from natural products were cited from the NCBI PubChem website, available online: https://pubmed.ncbi.nlm.nih.gov/ (accessed on 10 June 2021)
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