Abstract
Glioma is one of the most common tumors in China and chemotherapy is critical for its treatment. Recent studies showed that benzyl isothiocyanate (BITC) could inhibit the growth of glioma cells, but the mechanisms are not fully understood. This study explored the inhibitory effect of BITC on invasion and angiogenesis of U87MG human glioma cells in vitro and in vivo, as well as potential mechanisms. It was found that BITC could inhibit invasion and angiogenesis of human glioma U87MG cells by inducing cell cycle arrest at phase G2/M. It also was demonstrated that BITC decreased expression of cyclin B1, p21, MMP-2/9, VE-cadherin, CD44, CXCR4 and MTH1, the activity of the telomerase and PKCζ pathway. Microarray analysis was thus useful to explore the potential target genes related to tumorigenic processes. BITC may play important roles in the inhibition of invasion and angiogenesis of human glioma cells.
Highlights
Glioma is one of the most common cancer worldwide and most patients present with metastasis disease at diagnosis time
This study explored the inhibitory effect of benzyl isothiocyanate (BITC) on invasion and angiogenesis of U87MG human glioma cells in vitro and in vivo, as well as potential mechanisms
We focused on BITC and investigated its inhibitory effects on glioma U87 MG cell metastasis potential, and explored effects on U87 cell invasion and angiogenesis and related mechanisms
Summary
Glioma is one of the most common cancer worldwide and most patients present with metastasis disease at diagnosis time. Metastasis is a complex process, such as loss of cellular adhesion, increased invasiveness, entried to circulation, colonized into new tissue, and developed to metastasis site by cell adhesion molecules, extracellular matrix protein and tumor-related gene (Fidler, 2011). Recent studies showed that edible cruciferous plants, such as broccoli, cabbage and water celery, could reduce the risk of cancer. Benzyl isothiocyanate (BITC) is an active compound in edible cruciferous plants and it is showed anti-tumor activity in many types of tumor (Zhu et al, 2013). We focused on BITC and investigated its inhibitory effects on glioma U87 MG cell metastasis potential, and explored effects on U87 cell invasion and angiogenesis and related mechanisms
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