Potential Mechanisms Facilitating Herpesvirus-Induced Nuclear Remodeling: How are Herpesvirus Capsids Able to Leave the Nucleus?

Abstract

Herpesviruses replicate their DNA, assemble and package their capsids in the host nucleus. How capsids transverse the nuclear space to reach nuclear egress sites at the inner nuclear membrane has been a matter of some debate. We recently showed that HSV-1 and pseudorabies virus rely on the large-scale remodeling of host chromatin to allow intranuclear capsids to cross the nucleoplasm by diffusion. Which molecular pathways induce large-scale chromatin remodeling is currently not known. In this perspective, we propose a four-step speculative model that bridges the gap between known virus–host interactions and large-scale chromatin remodeling. We hope that this hypothetical framework will be used as a basis to elucidate how herpesviruses remodel the host nucleus and enable capsids to escape the nucleus.