Potential interactions in a cohort of elderly HIV-positive patients

Abstract

ObjectiveAn increased life expectancy leads to a new model of HIV patient with chronic diseases and occasionally polymedicated. With this study, we intend to understand treatment complexity and to identify any potential interactions between antiretroviral drugs and home medication in our patients, in order to identify and prevent them. MethodA retrospective, descriptive study carried out in a cohort of > 50-year-old patients on antiretroviral treatment in a tertiary hospital. ResultsWe included 242 patients; 148 (61%) of them were receiving some concomitant treatment. We detected 243 potential interactions: 197 considered moderate and 46 severe, in 110 patients. Of the severe interactions, 35 (76%) were related to boosted protease inhibitors.The main consequence of these interactions was an increase in the plasma concentrations of the home medication (48%).Statins (24%) were the group most involved in severe interactions, followed by inhaled corticosteroids (15%). ConclusionsPractically half of patients were polymedicated, and a high number of potential moderate or severe interactions were observed. The Hospital Pharmacist must play an essential role in their detection, management and early communication.