Abstract
Wound healing which is a usual biological process in our body is attained by four accurate and highly organized stages: hemostasis, inflammation, proliferation, and remodeling. In order to achieve a proper and successful wound healing, all these stages must occur in an appropriate sequence under a certain period of time. Many factors can disturb one or more stage of this process, hence resulting an inappropriate or ruined wound healing.Aim of research. This article investigates the influence of nanoceria on C-reactive protein and Middle-mass molecules concentration in blood serum of rats after full-thickness wound model.Materials and Methods. These two factors are considered to be indicators for endogenous intoxication, thus controlling their level in blood serum plays a key role in the wound healing process. The experimental procedure was conducted by the Gabrielyan method for Middle-mass molecules (MMM) concentration measurement and turbidimetry for C-reactive protein.Result. It was shown the elevated level of MMM in blood serum in the control group of rats. In contrast, where the treatment of wounds was carried out by Nanoceria in experimental group, the level of MMM decreased significantly in each day of experiment till 20th day when the full re-epithelialization occurred. And we demonstrated an increase in the level of CRP on the 3rd, 6th, 9th and 14th days of the experiment in comparison with the control in blood serum of all the experimental groups. Restoration of this indicator to normal values was observed in the groups of animals that received Nanoceria on the 20th day of the experiment, it correlated with full re-epithelialization.Conclusion. Due to several other advantages of Nanoceria, such as balancing some growth factors, Antioxidant, Antimicrobial, ROS reduction, SOD restoration, Catalase reduction properties that were investigated and proved in our previous studies, we consider Nanoceria as a promising drug for further investigation
Highlights
Wound healing is a pivotal physiological process in which cooperation of many cells and their products is needed
We are going to focus on the level of two factors, C-reactive protein and Middle-mass molecules, that are considered as endogenous intoxication during the wound healing process
Result The current study demonstrates the elevated level of endogenous intoxication markers (MMM) in blood serum in the control group of rats where Nanoceria was not applied on the wounds (Table 1)
Summary
Wound healing is a pivotal physiological process in which cooperation of many cells and their products is needed. Intentions for induced lesion restorement occur early at the inflammatory stage. Ending up to result in injured tissue repairment. We are going to focus on the level of two factors, C-reactive protein and Middle-mass molecules, that are considered as endogenous intoxication during the wound healing process. C-reactive protein, hereinafter CRP, is an acute inflammatory protein that increases up to 1,000-fold at Scientific Journal «ScienceRise: Biological Science». CRP is mainly synthesized in the liver and by lymphocytes, macrophages, smooth muscle cells, endothelial cells and adipocytes. When the tissue is injured, CRP level increases significantly in response to inflammation and infection (Fig. 1) [1]
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