Abstract
Potential human adaptation mutation of influenza A(H5N1) virus, Canada.
Highlights
Binding of the hemagglutinin from human or equine influenza H3 viruses to the receptor is altered by substitutions at residue 193
To the Editor: From March 30, 2013, through April 8, 2014, a total of 401 human infections with novel avian influenza A (H7N9) virus were reported in China [1]
An additional 4 RNA segments of A/Guangdong/H7N9 influenza viruses isolated after November 2013 were clustered with A/Guangdong/HZ-01/2013 virus and were divergent from all currently sequenced subtype H7N9 viruses from the first wave in eastern China
Summary
When mapped to the H5 HA protein structure by using FluSurver in GISAID (http://www.gisaid.org, http://flusurver.bii.a-star.edu.sg), both mutations are found in the immediate receptor-binding pocket, and G225R has been known to change specificity of an H3N2 virus toward human erythrocytes [2]. These receptor-binding pocket mutations of the virus were not seen in the most closely related Asian H5N1 sequences of clade 2.3.2.1c [1], and no human contacts were known to be affected.
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