Abstract
Therapeutic Role of Coenzyme Q10 in Brain Injury during Experimental DiabetesJihan Hussein, Dina Abo El-matty, Zakaria El-Khayat and Yasmin Abdel-Latif
Highlights
Oxytetracycline (OXT) is a broad-spectrum antibiotic that is widely used in controlling respiratory diseases and other genital and skin infections in human and animals
This study is the first to document the plausible protective efficacy of Coenzyme Q10 (CoQ10) against hepatorenal and reproductive toxicity induced by OXT in male rats
Our results indicate that OXT treatment significantly decreased body weight of rats and increased the relative liver and kidney weights
Summary
Oxytetracycline (OXT) is a broad-spectrum antibiotic that is widely used in controlling respiratory diseases and other genital and skin infections in human and animals. Large doses of OXT without medical supervision have deleterious effects on kidney and liver (Abdel-Daim and Ghazy, 2015). OXT was shown to exert its toxic effect via peroxidation of membrane lipids, mitochondrial damage, and impairment of the respiratory chain (Fromenty and Pessayre, 1997). Reduced tissue antioxidants biomarkers are associated with OXT overdose (Gnanasoundari and Pari, 2006). Several studies investigated the effect of antioxidants to counteract OXT-induced oxidative stress and to alleviate its side effects in experimental animal models. Supplementation of ascorbic acid (Naseer and Alam, 1987), Naringenin “natural flavonoid” (Gnanasoundari and Pari, 2006), and Curcumin (Helal et al, 2011) showed protective action against OXT detrimental effects on liver and kidney
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