Abstract
This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 μM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPARalpha mRNA in chrysin-treated MDA-MB-231 cells was significantly increased, which was likely associated to the proliferation of the cells post chrysin treatment.
Highlights
Chrysin is a natural phytochemical flavonoid belonging to the flavone group (Figure 1) which is ubiquitously found in fruits and vegetables [1,2]
To further elucidate these mechanisms, our study aimed to evaluate the effects of chrysin treatment on human estrogen receptor (ER)-negative breast cancer cells using MDA-MB-231 cell line as a model
The growth of MDA-MB-231 cells was significantly inhibited when the cells were treated with 20 μM of chrysin for 48 h, where the cell viability was reduced to 73.9% (p < 0.05)
Summary
Chrysin is a natural phytochemical flavonoid belonging to the flavone group (Figure 1) which is ubiquitously found in fruits and vegetables [1,2]. In particular, has been shown to have a broad range of pharmacological effects, including anti-oxidation, anti-viral and anti-inflammatory properties in a. Chrysin has been observed to reduce the risk of cancer and other major chronic diseases [1], and has been observed to display anti-cancer properties on breast cancer cells, though the mechanisms have not been well established [5]. To further elucidate these mechanisms, our study aimed to evaluate the effects of chrysin treatment on human estrogen receptor (ER)-negative breast cancer cells using MDA-MB-231 cell line as a model
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