Abstract
BackgroundEPO (erythropoietin) and PDGF (platelet derived growth factor) families are thought to be associated with angiogenesis under hypoxic condition. The sharp rise of intraocular pressure in acute primary angle closure (APAC) results in an inefficient supply of oxygen and nutrients. We aimed to measure the expression of EPO and PDGF family members in APAC eyes and demonstrate their associations with APAC’s surgical success rate.MethodsConcentrations of EPO, PDGF-AA, -BB, -CC and -DD collected in aqueous humor samples of 55 patients recruited were measured. Before operations, correlations between target proteins and IOP (intraocular pressure) were detected between APAC (acute primary angle closure) and cataract patients. Based on the post-operative follow-up, the effects of EPO and PDGF family members on the successful rate of trabeculectomy were tested.ResultsThe levels of EPO, PDGF-CC and -DD were significantly elevated in the APAC group compared to the cataract group. During the post-operative follow-up, EPO, PDGF-CC and -DD showed significant differences between the success and failure groups. In multivariable linear regression analyses, failed filtration surgery was more likely in APAC eyes with higher EPO level. The Kaplan-Meier survival plot suggested that the success rate in eyes with low EPO level was significantly higher than that in eyes with high EPO level.ConclusionThe levels of EPO, PDGF-CC and -DD were significantly elevated in failure group. EPO level correlated with preoperative IOP and numbers of eyedrops, and higher EPO level in aqueous humor is a risk factor for trabeculectomy failure. It can be a biomarker to estimate the severity of APAC and the success rate of surgery. The investigation of mechanism of EPO in APAC a may have potential clinical applications for the surgical treatment of APAC.
Highlights
Acute primary angle closure (APAC) is a common ophthalmic emergency
It was found that the EPO and two platelet-derived growth factor (PDGF) family members, PDGF-CC and PDGF-DD, had significant differences between the acute primary angle closure (APAC) and the control group (Table 2)
Our results showed that the EPO, PDGF-CC and PDGFDD levels were significantly elevated in the failure group (Table 5)
Summary
Acute primary angle closure (APAC) is a common ophthalmic emergency. The abrupt closure of trabecular meshwork in the anterior chamber angle causesWang et al BMC Ophthalmology (2021) 21:297 sharp rise of IOP in APAC results in an inefficient supply of oxygen and nutrients, which can lead to atrophy of anterior structures, the inflammation of anterior chamber, ischemia and hypoxia of the whole eye [1]. EPO is a pleiotropic cytokine that was first identified as being essential for red blood cell (RBC) production It plays a key role in the modulation of the response to injury, inflammation, and tissue hypoxia via the inhibition of apoptosis [7]. We aimed to measure the expression of EPO and PDGF family members (PDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD) in APAC eyes and demonstrate their associations with APAC’s surgical success rate. EPO (erythropoietin) and PDGF (platelet derived growth factor) families are thought to be associated with angiogenesis under hypoxic condition. The sharp rise of intraocular pressure in acute primary angle closure (APAC) results in an inefficient supply of oxygen and nutrients. We aimed to measure the expression of EPO and PDGF family members in APAC eyes and demonstrate their associations with APAC’s surgical success rate
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