Abstract
Background: Alpha lipoic acid has both hydrophilic and hydrophobic characteristics and is abundantly distributed in cellular membranes and the cytoplasm. It is among the top cell- protective antioxidants. Material and methods : The present work investigated the possible therapeutic effects of alpha lipoic acid in a male rat model of brain aging induced by D-galactose. Four equal-sized groups of 40 male rats were randomly assigned: G1, the control group, G2, and G3, which each received daily doses of 200 mg/kg of D-gal for 30 days. Alpha lipoic acid was given orally for 30 days to the G4 D-gal + alpha lipoic acid group at 200 mg/kg bw, IP. daily with 100 mg/kg. thirty days of IP. Glutamate is deposited in the brain, according to research on behavioral alterations and brain glutamate. Indicators of oxidative stress are increased Our Results show that whereas brain glutamate deposition declines in the D-gal model of aging, the Forced Swimming Test (FST) and Morris Water Maze Test considerably rise (MWM).
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