Potential Dynamic Imaging of Stationary Dual-Head SPECT with Multi-Pinhole Collimators in Human

Abstract

The stationary multi-pinhole (MPH) SPECT has the potential to achieve dynamic human myocardial perfusion imaging (MPI) with high sensitivity and high resolution. In this work, the sensitivity of MPH SPECT is 0.06%, four-fold higher than conventional SPECT (typically 0.015%), the dual-head SPECT was set up 77.6 degree. Acquisition time of stationary MPH SPECT was about 5 minutes, and Siemens Symbia T16 took approximately 15 minutes. For stationary MPH SPECT system, dedicated image reconstruction algorithm was developed. System calibration is necessary to ensure installation accuracy and obtain mechanical information for generating system transfer matrix, which will be employed to iterative reconstruction. Projection data were reconstructed using a Pixel-based Ordered Subset-expectation Maximization (POSEM) reconstruction algorithm with prior information. Reconstructed results showed that the image resolution obtained with stationary MPH is significantly better than Siemens Symbia T16, the image quality is also greatly improved compared to rotational LEHR SPECT. Meanwhile, the short acquisition time of MPH can reduce the possibility of artifacts due to patient movement. So it is potentially capable of dynamic 3D acquisition, and further more clinical trials for evaluating the system performances will be conducted.