Abstract
Objective: To evaluate prevalence, types and severity of drug-drug interactions in paediatric outpatient department. Methods: An observational study was carried out in Shree Krishna Hospital (SKH), a tertiary care teaching hospital after obtaining Institutional Ethics Committee approval. In SKH outpatient prescriptions are uploaded on software “Solace”, and these online prescriptions were collected from IT department. Potential Drug-drug interactions (pDDIs) were identified by using Medscape drug interaction checker. The prescriptions were analysed for demographic characteristics, medical and detailed drug history. Drug-drug interactions (DDIs) were evaluated for total numbers, types and severity of DDIs. Result: Total 300 prescriptions with mean age 6.33 ± 5.24 years were analysed. Total 96 pDDIs were recorded. The prevalence of pDDI was 16%. Most common pDDI was Valproic acid + Acetaminophen. There were 61 (63.54%) DDIs of pharmacokinetic, 24 (25%) pharmacodynamic and 11 (11.46%) had an unknown mechanism. Out of all interactions, 41 (42.71%) were of minor, 48 (50%) were of moderate and 07 (7.29%) were of severe in nature. The number of drugs prescribed and the occurrence of DDIs were significantly associated. ( p Key words: Drug-Drug Interactions, Paediatric, Pharmacokinetic, Pharmacodynamic, Prescription.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
