Potential drug targets in cyst-wall biosynthesis by intestinal protozoa.

Abstract

Given that resistance to antiprotozoal drugs exists and is likely to increase and given that currently no reliable treatments exist for some of these infections, efforts to find new targets for chemotherapy must be continued. In the case of cyst-forming pathogenic protozoa, one such target might be encystment pathways and cyst-wall assembly. Information is increasing on protozoan encystment and, as it does, we can begin to answer the question of whether targeting it for chemotherapy is a viable drug strategy. Currently, there are significant efforts to understand encystment in Giardia and Entamoeba, and potential targets are being discovered as work on their encystment mechanisms progress. We know with certainty now that Giardia and Entamoeba cyst walls contain unique proteins and polysaccharides which differ from those of their hosts and thus make them potentially interesting targets for a variety of chemotherapeutic attacks. Although we lack detailed information about the other protozoan cyst formers, enough evidence exists for Giardia and Entamoeba that it seems prudent to screen them with some of the antifungal drugs, especially those that target mannoproteins, chitin synthesis, and beta (1, 3) glucan synthesis to ascertain if they target elements in these protozoan pathways that are similar to those found in fungi.