Potential Drug Interactions between Antibiotics and Risk of Antimicrobial Resistance: A Database Research Study

Abstract

Background: When two antibiotics are used at the simultaneously, they interact. The interaction could be either synergistic or antagonistic. However, an antagonistic combination may halt the action of another antibiotic, resulting in the treatment failure and risk for the development of antimicrobial resistance. Materials and Methods: The Micromedex drug database was used to find potential antibiotic interactions among the antibiotics. The Micromedex drug database is a trustworthy database that can be used to examine various details such as drug information, interactions, disease information, and dose calculations. Results: As a result, 1923 antibiotic interactions were identified, which were divided into three categories: major, moderate, and minor. The interaction values were 1260 (65.52 %), 68 (3.53 %), and 595 (30.94 %) respectively. Among the 1923 interactions, 715 (37.18%) interactions were identified as risk for developing the AMR. The 715 interactions (37.18 %) were again grouped into three categories: major, moderate, and minor. The values are 354 (49.51%), 12 (1.67%), and 349 (48.81%), respectively. Conclusion: Antimicrobial resistance is a major public health concern around the world and it must be aware by everyone. All healthcare professionals look for potential drug interactions in the prescription and need to eliminate the risk of antimicrobial resistance that helps in improvement in the patient outcomes in terms of antimicrobial resistance.