Abstract
Emerging evidence demonstrated that circular RNAs (circRNAs) were dysregulated in lung cancer, indicating that circRNAs might serve as novel diagnostic and prognostic biomarkers for lung cancer. However, the clinical value of circRNAs on lung cancer remains unclear. This study aimed to evaluate the efficiency of circRNAs in the diagnosis and prognosis for lung cancer in China. 2122 Chinese individuals were enrolled in this investigation for assessment of diagnostic value and examination of prognostic analysis. In the diagnostic analysis, the pooled sensitivity, specificity, PLR, NLR, DOR, and AUC of the sROC curve with their 95% CIs were 0.80 (95%CI: 0.74-0.84), 0.80 (95%CI: 0.73-0.86), 3.97 (95%CI: 2.80-5.62) and 0.26 (95%CI: 0.19-0.34), 15.51 (95%CI: 8.76-24.47), and 0.85 (95%CI: 0.82-0.88), respectively. As for the prognostic power of circRNAs, lung cancer patients with higher expression levels of circRNAs tend to possess lower overall survival with the overall pooled HR (1.70, 95%CI: 1.26-2.29). Furthermore, in stratified analysis, upregulated and downregulated circRNAs were manifested to exert significant effects on prognosis with HR values of 2.17 (95%CI: 1.74-2.72) and 0.52 (95%CI: 0.34-0.80). This study validates that circRNAs are promising diagnostic and predictive biomarkers for lung cancer patients in China.
Highlights
Lung cancer is the most common of new cancer cases accounting for 11.6% of the new diagnosed cases and ranks as the leading cause of cancer death sharing 18.4% of the overall cancer mortality [1]
This study aimed to evaluate the efficiency of circRNAs in the diagnosis and prognosis for lung cancer in China. 2122 Chinese individuals were enrolled in this investigation for assessment of diagnostic value and examination of prognostic analysis
< 0.001 0.009 articles, results of studies were considered acceptable only based on the expression of circRNAs in tissue, while consequences of studies based on the expression levels of circRNAs in serum, plasma, or peripheral blood samples were not taken into account
Summary
Lung cancer is the most common of new cancer cases accounting for 11.6% of the new diagnosed cases and ranks as the leading cause of cancer death sharing 18.4% of the overall cancer mortality [1]. In males, lung cancer is the top one cancer type, responsible for newly diagnosed cancer patients and death, whereas lung cancer is the second death cause inferior to breast cancer and as for incidence rate comes in third behind breast cancer and colorectum cancer among females [1]. Diagnosis can make a huge difference to lung cancer patients, for providing the best opportunity for medical support [3]. If diagnosed at early stage, lung cancer patients with mild symptoms may be protected from developing severe, late-stage, and advanced cancer types, which will tend to require more intricate and expensive treatment with poorer curative effects. Immunotherapy, stem cells, and genomic medicine are emerging as novel attractive candidate strategies against cancer with striking treatment effect.
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