POTENTIAL COMPOUND DERIVED FROM CATHARANTHUS ROSEUS TO INHIBIT NON SMALL CELL LUNG CANCER (NSCLC)

Abstract

The a im of this study was to carry out GC - MS analysis of Catharanthus roseus plant leaves extract to inhibit the non - small cell lung cancer . Catharanthus roseus plant leaves were extracted with methanol and five compounds were identified from GC - MS analysis. Ep idermal growth factor receptor (EGFR), is a receptor tyrosine kinase (RTK) which is frequently over - expressed and malignant proliferation of n on - small cell lung cancer (NSCLC). The 3D crystal structure of the n on - small cell lung cancer responsible protein (ID: 2ITO) were retrieved from the protein data bank (PDB). Discovery studio is a well - known suite of software for molecular docking. It is developed and distributed by Accelrys. The protein ligand docking was performed in flexible docking by Discover Stud io. From the GC - MS analysis two compounds 4 - piperidineacetic,1 - acetyl - 5 - ethyl - 2 - [3 - [2 hydroxyethyl] - 1H - indol - 2 - yl] - a - methyl - methyl ester and 2H - Pyran,tetrahydro - 2 - [12 - penta decynyloxy], exhibit ed potential effect against human epidermal growth factor recep tor (EGFR) responsible for the non - small cell lung cancer .