Potential Combination of Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum and Momordica charantia Extracts Against Intake of Glucose in Muscle Rats-Induced Diabetes Mellitus

Abstract

Diabetes mellitus is a chronic condition that disturbs the body's blood sugarregulation. This disorder is characterized by a decrease in the ability of bodycells to intake glucose into cells. Due to the failure of cells in glucose intake,glucose buildup occurs in the extracellular, namely in the plasma. Thesemedicinal plants contain quite varied secondary metabolites, where theseplants are rich in flavonoids, alkaloids, terpenes and glycosides. The contentof these secondary metabolite compounds is believed to be rich in antioxidanteffects so that it has the effect of being able to suppress various oxidativestress conditions that cause damage to various organs due to blood sugardysregulation. The effect of Tinospora crispa, Andrographis paniculata,Cinamomum burmanii, Syzygium polyanthum and Momordica charantiaextracts on blood sugar levels and GLUT4 protein expression in muscle tissueshows the potential of the test extract's ability to improve blood glucose intaketo cells so as to maintain blood sugar regulation.