Abstract
Bell’s palsy can be considered as one of the most resistant and idiopathic neuromuscular facial diseases. It has not any specific effective treatments up to date in 2021. The aim of this article is to introduce this new Randomized Controlled Trial (RCT) which has the major objective of determining the proposed favorable positive effects and outcomes of integrating the triple herbal mixture of the black seed, licorice, and turmeric (In secure adequate doses) with the standard treatment (The standard of care) on the recovery of Bell’s palsy patients. The anticipated findings of this study are the faster recovery and enhanced nerve regeneration in Bell’s palsy patients taking appropriate doses of the black seed, licorice, and turmeric supplements within the treatment protocols.
Highlights
To date, Bell’s palsy is still idiopathic and very confusing
For the first time, integrating a triple herbal mixture of the black seed, licorice, and turmeric along with the traditional pharmacotherapeutic and physiotherapeutic treatment protocols for the sake of rapid and complete recovery in Bell’s palsy patients of all ages
The study is based on making use of the potent multiple activities of three of the most known and safe medicinal herbs, the black seed, licorice, and turmeric, mainly through their approved-use effective chemical compounds which are known for their successful potent anti-inflammatory, antioxidant, antiviral, and neuroprotective bioactivities [3,9,10,11], to address the issues accompanying the standard treatment in Bell’s palsy patients [1,5,6,8]
Summary
Bell’s palsy is still idiopathic and very confusing. It ranges in severity from slight weakness to total irritating paralysis of facial muscles (significant intense facial distortion) [1,5,6]. Licorice, and turmeric herbs with their major extremely potent bioactive ingredients (thymoquinone, glycyrrhizin, and curcumin, respectively) have excellent beneficial bioactivities (e.g., anti-inflammatory, antioxidant, antiviral, neuroprotective, and antimicrobial activities) that are needed in any Bell’s palsy case [9,10,11]. The study is based on making use of the potent multiple activities of three of the most known and safe medicinal herbs, the black seed, licorice, and turmeric, mainly through their approved-use effective chemical compounds (thymoquinone, glycyrrhizin, and curcumin, respectively) which are known for their successful potent anti-inflammatory, antioxidant, antiviral, and neuroprotective bioactivities [3,9,10,11], to address the issues accompanying the standard treatment in Bell’s palsy patients (e.g., severe facial inflammatory status, very slow facial nerve recovery, incomplete facial nerve regeneration, and intense facial distortion) [1,5,6,8]. Exclusion criteria: Patients < 15 years old or > 75 years old, suffering from hypertension/heart disease, sensitive/allergic to any of the herbal mixture ingredients/standard treatment medications, with bilateral facial paralysis, with concurrent neuromuscular and neurologic diseases, and/or having known inflammatory/neoplastic conditions
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