Abstract
Background: There is emerging molecular evidence concerning themodification of miR expression pattern after the treatment with chemopreventive agents. We investigated whether a potential chemopreventive agent called “Procont” deriving from a biological systemhas a positive effect on the DMBA induced dysregulation of let-7a, miR-21 and miR-146amiRNAs.Materials and Methods: CBA/CA H2k inbred micewere fed by Procont for 7 days before the intraperitonealinjection of DMBA. After one weekof the beginning of Procont diet weanalized the let7a, miR-21, miR-146agene expression in vital organs of mice. Results:The Procont feeding significantly decreased all of the investigated miRNA expression compared with either the mice on a normal diet in the control group or mice were exposed to DMBA alone.Conclusion:The results indicate that“Procont” diet has a potential chemopreventiveeffect in mice exposed to DMBA.
Highlights
There is emerging molecular evidence concerning the modification of miR expression pattern after the treatment with chemopreventive agents
In our previous study we investigated the effect of DMBA on the microRNA expression in CBA/CA H2k inbred mice after 24 hours and 1 week of the exposure (13)
The expression levels of miR21, miR146a and let7a were significantly higher in the vital organs of the mice after 24 hours of DMBA exposure compared to the control group
Summary
There is emerging molecular evidence concerning the modification of miR expression pattern after the treatment with chemopreventive agents. The expression levels of miR21, miR146a and let7a were significantly higher in the vital organs of the mice after 24 hours of DMBA exposure compared to the control group. POTENTIAL CHEMOPREVENTIVE EFFECT OF "PROCONT" ON MIRNA EXPRESSION IN CBA/CA MICE
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