Abstract
Potential Cardiovascular Drug Interactions in Egypt: Incidence, Outcomes, Mechanism, and Management
Highlights
With the increase of patients with multiple comorbidities, pharmacotherapy has become more complex increasing the risk of drug-drug interaction (DDI) in a great manner (Burger et al, 2005)
Drug monitoring, minimizing risk factors, and increasing awareness of potential drug interaction in cardiovascular diseases are recommended in clinical practice in Egypt
This study aims to identify the potential drug interactions with cardiovascular drugs for Egyptian outpatients giving insights about incidence, mechanisms, management, and preventions
Summary
With the increase of patients with multiple comorbidities, pharmacotherapy has become more complex increasing the risk of drug-drug interaction (DDI) in a great manner (Burger et al, 2005). Pharmacodynamic interactions occur if drugs have agonist or antagonist activities for both therapeutic efficacy and side effects (Pedro-Botet et al, 2015). Outcomes from DDIs include severe side effects causing hospitalizations and life-threatening conditions. In Egypt, potential drug interactions with the cardiovascular drug include both synthetic and herbal products. Ginkgo Biloba is a common herbal product usually written in prescription to enhance cognition and attention in Alzheimer’s. This herb showed potential drug interaction with factor Xa antagonist and aspirin increases the risk for bleeding. Herbs including plant products in common beverages and juices like green tea have the potential for drug interactions (Abdelkawy et al, 2015)
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