Abstract
Goniothalamus plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. Members of this family are rich in a wide variety of biological active compounds including alkaloids, acetogenins and styryllactones. The present research described phytochemical study of the leaves and twigs of G. marcanii together with their cytotoxicity. The G. marcanii was selected and percolated with hexane, ethyl acetate and methanol. The extracts were purified and elucidated chemical structures. The constituents of ethyl acetate extract of G. marcanii have been investigated. We isolated and identified three derivative styryllactones e.g., 5-hydroxygoniothalamin (1), 5-acetylgoniothalamin (2) and goniopypyrone (3). The structures of these compounds were elucidated on the basis of spectroscopic evidence. Studies on ethyl acetate extract of G. marcanii have now resulted the isolation and structural characterization of three styryllactones. Their anticancer activities were evaluated using SRB assays. In this method, compound 1 and 2 showed potential activity in cell lines.
Highlights
The genera Goniothalamus (Annonaceae family) consists about 160 species (Wiart et al, 2007), mostly distributed throughout the tropical and subtropical countries of Asia such as Malaysia and Thailand (Cao et al, 1998; Tip-Pyang et al, 2010). This genus has been studied for bioactive constituents due to their proven use in folk medicine for treatment of various diseases (Hisham et al, 2000) resulting the isolation of styryllactones, alkaloids, annonaceous acetogenins, flavonoids, azaanthraquinones and naphthoquinones (Cao et al, 1998; Tip-Pyang et al, 2010; Soonthornchareonnon et al, 1999)
We report the isolation and characterization of derivative styryllactones, 5-hydroxygoniothalamin (1), 5acetylgoniothalamin (2) and goniopypyrone (3) as well as their cytotoxicity
The cytotoxic activities of the tested extracts and compounds from G. marcanii were carried out using the in vitro Sulforhodamine B (SRB) method and ellipticine was used as a positive control
Summary
The genera Goniothalamus (Annonaceae family) consists about 160 species (Wiart et al, 2007), mostly distributed throughout the tropical and subtropical countries of Asia such as Malaysia and Thailand (Cao et al, 1998; Tip-Pyang et al, 2010) This genus has been studied for bioactive constituents due to their proven use in folk medicine for treatment of various diseases (Hisham et al, 2000) resulting the isolation of styryllactones, alkaloids, annonaceous acetogenins, flavonoids, azaanthraquinones and naphthoquinones (Cao et al, 1998; Tip-Pyang et al, 2010; Soonthornchareonnon et al, 1999). Chalong Mahiwan et al / American Journal of Applied Sciences, 10 (1): 112-116, 2013 diseases in early childhood (under 5 years old) Phytochemical investigation of this plant demonstrated the presence of 1-azaanthraquinone and naphthoquinone derivative which were possessed cytotoxicity against human tumor cell lines including lung carcinoma (A549), colonadenocarcinoma (HT-29), breast carcinoma (MCF-7), melanoma (RPMI) and brain carcinoma (U251), (Soonthornchareonnon et al, 1999). We report the isolation and characterization of derivative styryllactones, 5-hydroxygoniothalamin (1), 5acetylgoniothalamin (2) and goniopypyrone (3) as well as their cytotoxicity
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
