Potential biomarkers for esophageal cancer.

Cheng Tan,Baixia Yang,Xia Qian,Yangyang Ge,Jing Cai,Feng Wang,Zhifeng Guan

doi:10.1186/s40064-016-2119-3

Cheng Tan, Baixia Yang + Show 5 more

Open Access

https://doi.org/10.1186/s40064-016-2119-3

Copy DOI

Journal: SpringerPlus	Publication Date: Apr 16, 2016
Citations: 54	License type: CC BY 4.0

Affiliation: Nantong Tumor Hospital, Nantong University

Abstract

Esophageal cancer, which consist of esophageal adenocarcinoma and esophageal squamous cell carcinoma, is one of the most common malignant tumors in the world, especially in the south of Iran and China. To find and investigate the biomarkers in the initiation, development and progression of esophageal cancer will help us predict the prognosis of esophageal cancer patients and improve the curative effect and survival rate. Here, we reviewed the potential biomarkers of esophageal cancer in three aspects: Immunohistochemical markers, blood-based markers, miRNA markers and Gene expression profiling. All these biomarkers provided promising therapeutic targets for the diagnosis, treatment, and prognosis of esophageal cancer.

Highlights

Esophageal carcinoma (EC) is one of the most common malignant tumors in the world, with a wide distribution in the south of Iran and China (Zali et al 2011)
The results revealed that epidermal growth factor receptor (EGFR) expression in esophageal adenocarcinoma (EAC) is closely related to the pathological grade and lymph node metastasis, as well as poor disease-free and overall survival
In two independent samples of EC (n = 20 and n = 53, respectively), the expression of kindlin-2 was positively correlated with the activation state of the integrin signaling pathway and the PI3 K-AKT signaling pathway (P < 0.01). These findings suggested that kindlin-2 integrin β1-AKT can function as a regulatory master in the tumor suppressor function of miR-200b in esophageal squamous cell carcinoma (ESCC) patients

Summary

Introduction

Esophageal carcinoma (EC) is one of the most common malignant tumors in the world, with a wide distribution in the south of Iran and China (Zali et al 2011). The results revealed that EGFR expression in EAC is closely related to the pathological grade and lymph node metastasis, as well as poor disease-free and overall survival. The survival rate of ESCC patients with HER2-positive expression decreased, possibly because of increased radiation resistance (Dreilich et al 2006) and the use of cisplatin-based chemotherapy (Akamatsu et al 2003).

Results

Conclusion