Abstract
The purpose of this study was to explore the peptides that are related to acute reduction of blood pressure after alcohol drinking. Venous blood was collected from male healthy volunteers before and after drinking white wine (3 ml/kg weight) containing 13% of ethanol. Peptidome analysis for serum samples was performed using a new target plate, BLOTCHIP®. Alcohol caused significant decreases in systolic and diastolic blood pressure levels at 45 min. The peptidome analysis showed that the levels of three peptides of m/z 1467, 2380 and 2662 changed significantly after drinking. The m/z 1467 and 2662 peptides were identified to be fragments of fibrinogen alpha chain, and the m/z 2380 peptide was identified to be a fragment of complement C4. The intensities of the m/z 2380 and m/z 1467 peptides before drinking were associated with % decreases in systolic and diastolic blood pressure levels at 45 min after drinking compared with the levels before drinking, while there were no significant correlations between the intensity of the m/z 2662 peptide and % decreases in systolic and diastolic blood pressure levels after drinking. The m/z 1467 and 2380 peptides are suggested to be markers for acute reduction of blood pressure after drinking alcohol.
Highlights
Habitual alcohol drinking is known to show both beneficial and harmful effects on the risk of cardiovascular disease [1,2]
No abstainers were included in the subjects
By differential analysis among the three groups using ClinProTools 2.2 software, we found that levels of eighteen peptides were statistically different in the groups of “45 min after drinking” and “2–3 hr after drinking” compared with the levels in the group before drinking
Summary
Habitual alcohol drinking is known to show both beneficial and harmful effects on the risk of cardiovascular disease [1,2]. The exact mechanism for alcohol-induced hypertension remains to be clarified, the most likely hypothesis for the mechanism in heavy drinkers at present is increased sympathetic activity following withdrawal of alcohol [10,11,12]. In this hypothesis, a single intake of alcohol lowers blood pressure [13,14], and habitual daily alcohol intake
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
