Abstract
Covid-19 is terribly spreading around the globes and there is no stoppage. It is causing mass destruction in mankind allowing them to lock inside home to contain the disease. At present, there are no remedial medicines, drugs, or vaccines available in the market. Researchers are trying their best level to produce drugs to fight againts the disease. Various efforts are being considered by using different directions of scientific knowledge and technologies on treating the disease. The existing antiviral drugs such as lopinavir/ritonavir, pitavastatin, nelfinavir, perampanel, and praziquantel are being administered as remedies of covid-19 patients. Unfortunately, none of these drugs works absolutely against the current pandemic. Therefore, bioactive molecules from plants, animals, and microorganisms could be a better option to treat against the covid-19 and its family. Plants can treat many diseases due to the presence of bioactive molecules and their antiviral properties. Presence of secondary metabolites such as flavonoids, alkaloids, terpenoids, polyphenols, curcumin, kaempferol, catechin, naringenin, quercetin, apigenin-7-glucoside, luteolin-7-glucoside, demethoxycurcumin, oleuropein, and epigallocatechin can fight against the coronavirus including covid-19. The listed plants such as litchi seeds, Houttuynia cordata, Chinese Rhubarb extracts, beta-sistosterol from Isatis indigotica root extract have capacity to obstruct the enzymatic activity of SARS. In this article, we have highlighted the bioactive molecules from different plants, animals, and microorganism and their potential activity against the coronavirus. It is a need of the hour to come together to explore more on such bioactive compounds of plants, animals and other microorganism to fight against the covid-19.
Highlights
The scariest and terrifying problem hammering over our head is covid-19
As a preventive measure to fight against the covid-19, some strategies like social distancing, stay home stay safe, self-quarantine, maintaining hygiene, wear masks and use hand sanitizer can be mentioned
The only one-way hope for the present situation is to rely on bioactive molecules from natural products as they have antiviral properties against the covid-19
Summary
The scariest and terrifying problem hammering over our head is covid-19. In the current century for human race covid-19 is a problem that seems to be with zero solution by looking at the present situation. Covid-19 shows various symptoms like pneumonia, fever, breathing difficulty, and many more due to lung infections These symptoms are similar to the corona virus (CoV) occurred in 2003 as severe acute respiratory syndrome (SARS). It is reported that lopinavir/ritonavir drugs generally used for the treatment of human immunodeficiency virus HIV and can be administered as remedies of covid-19 patients (Wang et al 2020a, b, c). The study conducted by molecular docking and bioactive compounds like rutin, diacetyl curcumin, diosmin, beta, beta-(4-Methoxy-1,3-phenylene) bis(2`-hydroxy-4`,6`-dimethoxyacrylophenone), (E)-1-(2Hydroxy-4-methoxyphenyl)-3 [3-[(E)-3-(2-hydroxy-4methoxyphenyl)-3-oxoprop-1-enyl] phenyl] prop-2-en-1-one and apiin released from medicinal plants have therapeutic properties against covid-19 (Adem et al 2020). 3-chymotrypsin-like protease have therapeutic capacity against SARS-CoV, so by using such compounds, human corona virus including SARS-CoV-2 can be treated (Yang et al 2020). It was known that an impressive medicine,
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