Abstract
In the present scenario of pharmaceutical development, researchers are focusing on the herbal excipients for different delivery systems. This work describes diverse characteristics of novel polysaccharide extracted from the stem of Abelmoschus moschatus (AM). Further, polysaccharide was explored for its potential role as polymer in controlling colon-specific release of metronidazole (MNZ). Cell toxicity study confirmed its safety aspects in biological applications. The aqueous solution of polysaccharide exhibited non-Newtonian pseudoplastic flow property. The consistency coefficient (k) was found to increase with increase in concentration and particle size of AM polysaccharide. Viscosity was found to increase by increasing pH of the aqueous solution of AM. In-vivo gamma scintigraphy study of radiolabeled MNZ tablet in human volunteers confirmed small intestinal transit time of 300–480 min and colon arrival time of 360–480 min. The present study revealed that AM polysaccharide may be a choice of pharmaceutical excipients as an alternative to synthetic polymers.
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