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Abstract
Purpose To preliminarily evaluate the feasibility and potential of using 68Ga-PSMA-11 PET/CT in evaluating the function of salivary glands and lacrimal glands in comparison with 99mTc-pertechnetate (99mTcO4−) salivary gland scintigraphy (SGS). Methods A retrospective study was performed in 15 patients with different degrees of xerostomia and suspected salivary gland dysfunction. Each patient underwent 68Ga-PSMA-11 PET/CT first and SGS the next day, and the findings of both scans were compared. Results The results of 68Ga-PSMA-11 PET/CT and SGS were consistent in 12/15 patients (80%) and were inconsistent in the remaining patients (20%). For 5 (33.3%) of 15 patients, 68Ga-PSMA-11 PET/CT provided more information than did SGS. Additionally, 68Ga-PSMA-11 PET/CT corrected the misdiagnosis by SGS for 1 patient. Conclusions 68Ga-PSMA-11 PET/CT is a potentially useful imaging tool for evaluating the function of salivary glands and lacrimal glands. 68Ga-PSMA-11 PET/CT can be a promising supplement to SGS, and its clinical value deserves further study.
Highlights
Introduction e salivary glands consist of three pairs of major salivary glands and multiple minor salivary glands that are widely distributed in the oral mucosa
Results e general information and positron emission tomography (PET) and salivary gland scintigraphy (SGS) imaging results for all 15 patients are shown in Table 1. is study included 4 patients with Sjogren’s syndrome, 10 patients with head and neck tumors after radiotherapy and chemotherapy, and 1 patient with surgery for parotid space-occupying lesions
SGS is a planar SPECT imaging technique, while 68GaPSMA-11 PET/CT is a positron emission computed tomography fusion imaging technique. 68Ga-prostate-specific membrane antigen- (PSMA-)11 PET/ CT can provide functional metabolic and anatomical images with higher resolution than SGS. 68Ga-PSMA-11 PET/CT can accurately assess the morphology of the gland and the degree of atrophy to evaluate gland function more accurately
Summary
Most of the current studies use objective indicators as a more convincing means of evaluation because the subjective symptoms of patients do not necessarily re ect the dysfunction of salivary glands [3, 4]. E objective evaluation methods of clinical salivary gland function mainly include saliva analysis, radiography of the parotids, and 99mTc-pertechnetate (99mTcO−4 ) salivary gland scintigraphy (SGS). SGS is a commonly used method for the clinical evaluation of salivary gland function and has high speci city and Contrast Media & Molecular Imaging sensitivity [6]. E purpose of this study was to explore the value of 68Ga-PSMA-11 PET/CT in evaluating salivary and lacrimal gland function and whether 68Ga-PSMA-11 PET/CT has a complementary or alternative role to SGS
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