Abstract
Natural products play a vital role in drug discovery. Metabolomics, the systematic analysis of small molecular metabolites in biological systems, has been increasingly applied to discovering biomarkers, identifying perturbed pathways and discovering new drugs. It enables the examination and identification of endogenous biochemical reaction products occurring within a living cell. Cell metabolomics has many potential applications and advantages to currently used methods at various aspects in the natural product era. This review covers recent developments in the use of metabolomics to characterize cellular metabolome and interpret them in terms of metabolic changes taking place in a wide range of situations, especially, highlights the key roles of the endogenous small-molecule metabolites in the natural product field.
Highlights
Metabolomics is an emerging and powerful discipline that provides an accurate and dynamic picture of the phenotype of mammalian systems through the study of endogenous and exogenous metabolites in cells, and culture supernatants [1]
The diverse potential of metabolomics in many fields, including cell engineering, has made it a universal tool for industrial, medical and research purposes. It is a vital component of a ‘systems biology’ approach, as it is believed to be a good reflection of the phenotype of any cell or tissue [40]
The purpose of this review is to describe the state of the art of a new emerging discipline, cell metabolomics in the understanding how the metabolites affect cell behavior and function and highlight the past successes in applications of cell metabonomics to contribute to low-molecular-weight metabolites discovery in natural products
Summary
Metabolomics is an emerging and powerful discipline that provides an accurate and dynamic picture of the phenotype of mammalian systems through the study of endogenous and exogenous metabolites in cells, and culture supernatants [1]. A dramatic change in the pharmaceutical industry as many companies are downscaling their efforts to discover new drug candidates and are instead turning toward natural products that are the source of many active substances in drug discovery. This trend has been dubbed open innovation. Cell applications are easier to control, less expensive and easier to interpret than analysis of both animal models and human subjects As such, they represent an untapped resource for identification of specific metabolite biomarkers that would help distinguish the normal, and abnormal states, as well as response to drugs [7,8,9]
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