Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases

Weiping Liu,Zhiqiang Shen,Zhihe Chen,Ling Li,Yikun Yang,Huizhou Xiong

doi:10.1155/mbd.1998.123

Abstract

The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On cereral ischemia model pretreatment with 0.018mmol/kg copper aspirinate ig significantly increased survival of animals and the density of intact hippocampal CA1 cells and decreased brain calcium concentration. Its anticerebral ischemia activity was superior to or equal to nimodipine. It is, therefore, suggested that copper aspirinate is very promising in becoming an antithrombotic drug in preventing and treating thrombotic diseases.

Highlights

Copper aspirinate is a copper complex of aspirin and has been demonstrated to be more active as an antiinflammatory agent and less irritant tom the digestive tract than aspirin [1][2]
Effects of copper aspirinate on the tail bleeding time and on the mice mortality caused by arachidonic acid (AA) are listed,respectively, in Table 1 and 2
These data show that ig administration of 0.012mmol/kg copper aspirinate for 7 days,significantly prolonged bleeding time and inhibited AA-induced mortality

Summary

Introduction

Copper aspirinate is a copper complex of aspirin (see Fig. l) and has been demonstrated to be more active as an antiinflammatory agent and less irritant tom the digestive tract than aspirin [1][2]. Groups of 10 ICR mice were given copper aspirinate, aspirin or the vehicle intragastrically (ig) for 7 days,and the tail bleeding time of each group was measured using Wang’s method [6]. Groups of 30 IRC micofter administrated with copper aspirinato or aspirin or vehicle ig for 7 days, were injected with 80mg/kg AA in the tail vein to induce thrombosis [7] ,the number of mice dying in each group was recorded and the mortality calculated (Tal’ 2).

Results

Conclusion