Abstract
A series of N, N-dialkylaminoalkyl aniline derivatives were designed and prepared to elicit selective antihistaminic activity. As a result of the relative polarity of these compounds, undesirable CNS, adrenergic, and anticholinergic activities are expected to be less than those of the more lipophilic antihistaminic compounds. The intermediate substituted aniline derivatives were prepared by base-catalyzed substitution of aniline and were then N-acylated with 2-bromopropionyl bromide. Characterization of the synthesized compounds was accomplished by elemental analyses and IR and NMR spectroscopy.
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