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Abstract
Background: Deregulation of the gut microbiota results in various pathological disorders such as diabetes, inflammation, cancer, dyslipidemia etc. Modulation of intestinal microbiota by probiotics may facilitate the management of a number of clinical conditions of diabetes. Methods: The present study was designed to investigate the effect of feeding low-fat probiotic yogurt containing L. acidophilus and L. bulgaricus on fructose-fed hyperglycemic rats. Yogurt containing L. acidophilus or L. bulgaricus (9.5 × 109 cfu/rat/day) alone or in combination of both strains was supplied orally for 8 weeks concurrently with 20% fructose solution. Fasting blood glucose (FBG), oral glucose tolerance test, glycosylated hemoglobin (HbA1c), lipid profiles from blood and histopathological study of liver tissues were analyzed to evaluate anti-diabetic effect. Statistical analysis was done by Graph Pad Prism software. Values at p 0.05 were considered statistically significant. Results: Administration of L. acidophilus or L. bulgaricus alone or in combination of both to hyperglycemic rats decreased serum FBG, onset of glucose intolerance, HbA1c, total cholesterol, triglycerides, LDL and VLDL-cholesterol, increased HDL-cholesterol levels significantly and preserved antioxidant pool such as activities of superoxide dismutase, catalase etc. Probiotic administration also prevented/repaired the oxidative damage of liver tissues. Conclusion: In conclusion, administration of yogurt containing L. acidophilus or L. bulgaricus that balanced the intestinal microbiota can prevent or lower risks of type-2 diabetes and its related complications.
Highlights
Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development [1]
Probiotics may be involved in the maintenance of a healthier gut microbiota that would be beneficial for the management of diabetes
The present study aimed to investigate the effect of probiotic, lactobacillus (L) strains, L. acidophilus and L. bulgaricus in the form of functional food, yogurt, against fructose-fed hyperglycemic rats
Summary
Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development [1]. Scientific evidences suggest that increased inflammatory stress is related to molecular mechanisms leading to insulin resistance, and the intestinal microbiota interacts with environmental factors and susceptible genetic factors, contributing to the development of diabetes [5] [6] [7]. Deregulation of these microbiota component results in various pathological disorders such as cancer, diabetes, cardiovascular diseases, dyslipidaemia etc. Conclusion: In conclusion, administration of yogurt containing L. acidophilus or L. bulgaricus that balanced the intestinal microbiota can prevent or lower risks of type-2 diabetes and its related complications
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