Abstract
Cervical cancer is common in women in less developed regions of the world. The plant biomolecules can be employed for synergistic activity with chemo- and radiotherapy. This combinations might result in reduced toxicity and increased efficacy of the treatment regimen. The anti-HeLa cells activity of the acetone extracts of S. plumosum, T. cilliata and S. pinnata was assessed using different parameters. Secondary metabolite detection and antioxidant activity quantification were determined using the DPPH and ferric iron reducing assays. HeLa cell growth inhibition and mechanistics were assessed by employing MTT and Annexin-V flous assays. Observations revealed the presence of phenolic, flavonoids, tannins steroids and coumarins in all the plants extracts. High amount of total phenolic and flavonoid content were detected in S. plumosum and T. cilliata. S. plumosum extract had the best DPPH scavenging activity and ferric reducing powers. Observable concentration dependent cell proliferation inhibition by test materials was exhibited. The leaf extracts from T. cilliata, S. plumosum and S. pinnata contain compounds of various polarities with free-radical, antioxidant and anti-cancerous activities that may play a beneficial role in treatment.
Highlights
The prevalence of cervical cancer has reached alarming global levels where in 2010 it was reported to be 4-fold higher prevalence of cervical cancer in low to middle-income countries[1]
The present study focused on the anti-proliferative effects of acetone extracts of selected medicinal plants on proliferation of a HeLa cancer cell line, antioxidant activity, secondary metabolites, phytochemical constituencies and apoptotic effects
S. plumosum and S. pinnata were collected from Mankweng and T. cilliata from Tzaneen in Limpopo province, South Africa
Summary
The prevalence of cervical cancer has reached alarming global levels where in 2010 it was reported to be 4-fold higher prevalence of cervical cancer in low to middle-income countries[1]. The present study focused on the anti-proliferative effects of acetone extracts of selected medicinal plants on proliferation of a HeLa cancer cell line, antioxidant activity, secondary metabolites, phytochemical constituencies and apoptotic effects. The plant biomolecules can be employed for synergistic activity with chemo- and radiotherapy. This combinations might result in reduced toxicity and increased efficacy of the treatment regimen. Objectives: The anti-HeLa cells activity of the acetone extracts of S. plumosum, T. cilliata and S. pinnata was assessed using different parameters. The leaf extracts from T. cilliata, S. plumosum and S. pinnata contain compounds of various polarities with free-radical, antioxidant and anti-cancerous activities that may play a beneficial role in treatment. Potential anticancer activity of Acetone extracts of Toona cilliata, Seriphium plumosum and Schkuhria pinnata on HeLa cervical cancer cells.
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