Potential anti-diabetic property of the aqueous extract of the leaves of Saba senegalensis Pichon (apocynaceae) in mice

Dosso Mamadou,Coulibaly Adama,Soro Doudjo,N'guessan J. David,Coulibaly Ousmane

doi:10.14419/ijpt.v8i1.30635

Abstract

This study made it possible to demonstrate that Saba senegalensis has hypoglycemic and anti-hyperglyvemic effects in mice. The aqueous extract of Saba senegalensis from 75 to 250 mg / Kg bw causes a dose-dependent hypoglycemia ranging from 4.84 to 34.62% (p <0.01-0.05), in normoglycemic mice, 60 minutes after treatment. The Glucose-Induced Hyperglycemia Orally (OPGH) test showed that in the presence of Saba senegalensis aqueous extract at a concentration between 75 and 250mg/Kg bw, the glucose-induced hyperglycemic peak (3g/Kg bw) is reduced from 26.49 to 71.77% (p < 0.01-0.05), 30 minutes after treatment. Oral administration of the aqueous extract of this plant in doses up to 5000 mg / Kg bw resulted in no deaths in mice during two weeks of observation.Â Â Â

Highlights

Diabetes is a metabolic disease, characterized by chronic hyperglycemia (American Diabetes Association 2002)
The objective of this study is to evaluate the hypoglycemic and anti-hyperglycemic effects of the aqueous extract of Saba senegalensis
Glibenclamide 10mg / Kg bw, 48.94% drop in blood sugar after one hour of treatment. These results indicate that, the aqueous extract of Saba senegalensis, like glibenclamide, has a hypoglycemic effect in normoglycemic mice

Summary

Introduction

Diabetes is a metabolic disease, characterized by chronic hyperglycemia (American Diabetes Association 2002). Saba senegalensis of the family Apocynaceae, which requires a lot of sunlight, is native to tropical Africa (Arbonnier, 2002) It is a Sudanian and Guinean plant, occurring from Senegal to Nigeria via Côte d’Ivoire, Mali and Burkina Faso (Sarr et al, 2018). The phytochemical study of the leaves indicates that its aqueous extract contains tannins, saponins and flavonoids (Sarr et al, 2015), chemical groups known for their hypoglycemic properties (Masunda et al, 2014, Kambouche et al, 2009) Aided by this phytochemical content and in order to contribute to the pharmacological study of this plant for which little tangible scientific information is available to date, this study will evaluate:

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