Abstract
By mixing 5-bromo-2-furaldehyde, phenylthiosemicarbazide and Bi(CH3COO)3, a new amorphous bismuth-containing complex, BiL2Cl3, was synthesized under aqueous conditions via a one-pot method and characterized with some analytical techniques, where L was produced by dehydration between 5-bromo-2-furaldehyde, phenylthiosemicarbazide. The obtained complex effectively inhibited the proliferation and migration of A549 and H460 lung cancer cells, induced cell apoptosis and displayed fairly low cytotoxicity to normal human lung fibroblast (HLF). Compared with cisplatin, BiL2Cl3 displayed better anti-cancer activity against tumor cells and lower toxicity to normal cell. Therefore, BiL2Cl3 with potent anti-cancer activity may be a viable drug candidate in anti-cancer therapies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.