POTENTIAL ANALGESIC AND ANTI-INFLAMMATORY EFFECT OF CUMINUM CYMINUM AND BORAGO OFFICINALIS IN RATS AND MICE

Gihan F Asaad Gihan F Asaad,Yousra Nomier Yousra Nomier,Alaa O Hakami Alaa O Hakami,Saeed Alshahrani Saeed Alshahrani,Alaa Q Redai Alaa Q Redai,Fatimah Y Ghazwani Fatimah Y Ghazwani

doi:10.22159/ajpcr.2020.v13i1.36107

Gihan F Asaad Gihan F Asaad, Yousra Nomier Yousra Nomier + Show 4 more

Open Access

https://doi.org/10.22159/ajpcr.2020.v13i1.36107

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Abstract

Objective: Our research aimed to study the potential therapeutic effect of Cuminum cyminum and Borago officinalis seed oil against inflammation induced by carrageenan as well as its central and peripheral analgesic effect. Methods: The anti-inflammatory effect was determined by measuring the edema rate and inhibition rate using Plethysmometer. Writhing test and hot plate test were used to determine the peripheral and central analgesic effect, respectively. Key Findings: Significant anti-inflammatory effects were witnessed for all the drugs at different dose levels in the results. Substantial analgesic effect against both peripheral and central pain induction was also incurred on administration of all doses of C. cyminum and B. officinalis seed oil. Conclusion: The C. cyminum and B. officinalis seed oil has potent anti-inflammatory and analgesic effects.

Highlights

Inflammation is a normal protective response induced by tissue injury or infection to combat invaders in the body and to remove dead or damaged host cells
The potential anti-inflammatory effect of borage seed oil and cumin seed oil against Carrageenan induced inflammation was tested in 30 Wistar rats weighing 150–200 g
Edema rates were monitored throughout the experiment at an interval of 1, 2, and 3 h after Carrageenan injection, and results were analyzed and compared with both control and reference groups

Summary

Introduction

Inflammation is a normal protective response induced by tissue injury or infection to combat invaders in the body (microorganisms and non-self-cells) and to remove dead or damaged host cells. Nonsteroidal anti-inflammatory drugs reduce pain and inflammation by inhibiting PG production through inhibiting cyclooxygenase (COX) enzyme activity (Cox 1 and Cox 2). Borage is useful in lowering levels of glucose, cholesterol, and triglycerides which can exert anti-carcinogenic effect [3]. Diet with borage oil enhances the levels of linolenic and arachidonic acid in plasma, liver, and vascular tissues. It might exert antihypertensive effect in rats [4], reduce menopause, and premenstrual syndrome [5]

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