Potential action of SAGE extracts to prevent the growth of bacteria isolated from patients suffering from diarrhea and one type of cancer cell

Abstract

Now, the trend has begun to use some types of herbs, including salvia sage, in the development of medicines and medicinal drugs instead of synthetic drugs because they are antimicrobial and are considered preservatives against food spoilage. Sage is also an aromatic material used as a food flavoring. This work represented examining the antibacterial impact of the sage extract on four types of pathogenic and drug-resistant bacteria in vitro, like Staphylococcus aureus, Escherichia coli, Pseudomonas eruginosa, besides Klebsiella pneumonia, Providencia, and Burkholderia. On the other hand, cytotoxic effects of the ethanol extract of Salvia showed antitumor activity on MCF-7 cells in a dose-dependent manner as the cell viability against MCF-7 cells was decreased with an IC50 of μg/ml. The experimental study of the antibacterial influence of extracted sage plants from ethanol on the evolution of multi-drug resistant bacteria was fulfilled with good diffusion at different concentrations: 50, 150, 200 mg/mL, and microdilution methods. Disclose the impact of the sage methanol extract on MCF-7 cell viability. In our study, Ethanol extracts of sage in the good diffusion method displayed obvious notable inhibitory against bacterial growth. These results refer to the inhibitory impacts of ethanol extract of sage with MIC (Minimum Inhibitory Concentration)=8 mg/mL owing to S.aureus, MIC=5 mg/mL for E. coli, MIC=4.4 mg/mL owing to P. aeruginous, MIC=4.2 mg/mL owing to Burkholderia, MIC=5.7 mg/mL owing to Klebsiella pneumonia. The impact found with Providencia. Results indicated a dose-dependently growth inhibition (63.18% at 250 µg mLG1 ). Concerning the antibacterial impact of ethanol extracts of Sage on the multi-drug impervious to bacteria, the use of herbs as a replacement to antibiotics after pharmacological studies for treatment is recommended. Methanol extract of sage exhibited profound cytotoxicity activity against the MCF-7 cell line. Keywords: Salvia sclarea, sage, Antibacterial activity, cytotoxicity, MCF-7 cell line.