Abstract
Novel series of quinoline derivatives incorporating cyclopropyl ring and sulfone linkage as substituents have been synthesized, and oxidation of ethyl-2-cyclopropyl-4-(substituted phenylthio)quinoline-3-carboxylate was carried out to set ethyl-2-cyclopropyl-4-(substituted phenyl sulfonyl)quinoline-3-carboxylate. An ecofriendly synthesis of sulfone derivatives was carried out by the reaction of glacial acetic acid and 30% hydrogen peroxide at room temperature. The synthesized quinoline incorporating sulfone linkage derivatives was evaluated for their anticipated antimicrobial activity as well as characterized by their melting point, mass spectra, IR, 1H NMR and 13C NMR spectra. For proving the structural biological activity, herein we have carried out SAR and HOMO–LUMO studies. From these studies, we have found some best results as their energy gap is very low which makes their activity higher, i.e. compounds 11a, 11b, 11h, 11k and 11m.Graphical abstract
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