POTENT BIOLOGICAL AGENT BENZIMIDAZOLE–A REVIEW

Abstract

<p>Benzimidazole nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. Numerous method for the synthesis of benzimidazole and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Various reported biological activities (analgesic, anti-inflammatory, anthelmintic, anticancer, anthelmintic, antioxidant, antitubercular, and antiviral activity) of bezimidazole are collected and summarized here. Large numbers of drugs are available to treat various diseases, but they are associated with some drawbacks like resistance, toxicities and other adverse effects. To combat with these problems there is need to discover and synthesize newer chemical entities with better efficacy and novel mechanism of action. The benzimidazole ring is an important pharmacophore in modern drug discovery. The synthesis of novel benzimidazole derivatives remains a main focus of medicinal research. There is still scope for more research work to be done in this field to find a novel agent. The versatility of new generation benzimidazole would represent a fruitful pharmacophore for further development of better medicinal agents. Therefore this substrate has a tremendous scope for the discovery of new, better, safe and more potent biological agents.</p>