Abstract
Newcastle disease virus (NDV) causes serious infectious diseases in birds, affecting poultry production. In addition to adverse side effects, almost all conventional drugs targeting viral proteins have drug resistance mutations. This study aimed to evaluate the antiviral activity of green silver nanoparticles using green tea leaf extract as a new strategy to control NDV in ovo. The Log embryo infective dose50 (EID50) virucidal reduction was used to measure the antiviral activity of silver nanoparticles against NDV. The treatment of Vero cells with the silver nanoparticles (AgNPs) at a noncytotoxic concentration significantly therapeutic value by inhibiting NDV entry and reduced viral replication, which led to a great reduction in the viral titer in ovo. In conclusion, silver nanoparticles are effective as a therapeutic antiviral agent against NDV and inhibit microbial resistance by making it difficult for the microbe to adapt.
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