Potent Anticancer and mTOR Inhibitor Activities of Some Synthesized Linear and Macrocyclic Pyridine Derivatives

Abstract

A series of linear and macrocyclic 2,6-disubstituted pyridine derivatives 1–7 were previously prepared and evaluated as analgesic and anticonvulsant agents. Herein these derivatives were screened as anti pancreatic cancer, anti-GIT cancer and mTOR inhibitor activities. The tested compounds were found to have in vivo and in vitro potent anti-pancreatic cancer and anti-GIT cancer activities. The mechanism of action of these compounds was evaluated as mTOR inhibitors.