Abstract
The role of calcium in interleukin- (IL) 8-, IL-1α- and IL-1β-induced lymphocyte migration has been investigated by using the calcium channel antagonists, verapamil, nifedipine, diltiazem (IL-8) and the optical isomers of the dihydropyridine analogue SDZ 202–791 (IL-8, IL-1α and IL-1β). Potent inhibition of IL-8-induced migration was observed in response to nifedipine (IC 50=10nM), verapamil (IC 50=60nM) and diltiazem (IC 50=10nM). The (+)-isomer of SDZ 202–791 was without effect on any of the agonists tested, however, the (−)-isomer induced dose-related inhibition of stimulated migration, IC 50 values being 0.1nM, 10pM and 1.0nM, for IL-8-, IL-1α- and IL-1β-induced migration, respectively. Reversal of the inhibitory effects of the (−)-isomer was obtained in the presence of increasing concentrations of (+)-isomer. The induction of lymphocyte migration by IL-8, IL-1α and IL-1β therefore appears to be a process dependent on calcium channel activation.
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