Abstract
The condition of the heart experiencing changes is called Coronary Heart Disease namely, changes in body cells that encourage organ work. According to the 2018 Basic Health Research, coronary heart disease in Indonesia is 1.5% or is estimated to be 883,447 people and for East Kalimantan it is 1.9% or as many as 13,977 people. The use of a lot of drugs, often occurs in coronary heart patients with additional comorbiditiens that require doctors to prescribe more than one drug to overcome the complaints suffered by the patient. The purpose of this study was to determine the interaction of the use of drug in patients with coronary heart disease and additional comorbidities. The concept was carried out using a random sampling data collection method in the form of taking outpatient prescription data at the cardiac polyclinic for 1 year, from January to December 2021. There were 242 patients, 59.1% male and 40.9% female. The highest comorbidities, of the 7 comorbidities with the most patients being hypertension, amounted to 122 and followed by diabetes mellitus 40 patients. The highest drug interactions were found in 108 clopidogrel and lansoprazole drugs, 31 spironolactone and furosemide drugs, and 26 simvastatin and amlodipine. With the incidence of drug interactions as many as 218 of 242 samples.
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