Abstract
A number of batches of tetanus toxin prepared by means of the ‘Mueller medium’ were fractionated with ammonium sulphate. The purity and the immunizing potency of the resulting fractions were determined. The fractions precipitated at low A.S. concentrations are very potent but not very pure, those precipitated at high A.S. concentrations have a low potency and are very impure. Medium concentrations (about 15–25% A.S.) yield a product which is highly satisfactory with respect to both purity and potency and forms a suitable basis for the preparation of a vaccine. The various batches of toxoid did not differ significantly in potency.
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